منابع مشابه
Autophagy in Inflammatory Diseases
Autophagy provides a mechanism for the turnover of cellular organelles and proteins through a lysosome-dependent degradation pathway. During starvation, autophagy exerts a homeostatic function that promotes cell survival by recycling metabolic precursors. Additionally, autophagy can interact with other vital processes such as programmed cell death, inflammation, and adaptive immune mechanisms, ...
متن کاملAutophagy, NLRP3 inflammasome and auto-inflammatory/immune diseases.
Loss of homeostasis, as a result of pathogen invasion or self imbalance, causes tissue damage and inflammation. In addition to its well-established role in promoting clearance of pathogens or cell corpses, inflammation is also key to drive tissue repair and regeneration. Conserved from flies to humans, a transient, well-balanced inflammatory response is critical for restoration of tissue homeos...
متن کاملAutophagy in Chronic Kidney Diseases.
BACKGROUND Autophagy is the degrading process of protein and organelles mediated by lysosomes. This process is involved in purging senescent organelles and subversive proteins while maintaining the stability of the intracellular environment. This phenomenon is highly conservative, existing in nearly every species, and is involved in cell growth, proliferation and tumorigenesis. SUMMARY In rec...
متن کاملPeripheral blood smear in infection and inflammatory diseases
Peripheral blood smear study is very useful tool in early diagnosis of some infection and inflammatory diseases. In present article morphological changes of blood cells will be discussed in general infection and in viral infection such as HIV, H1N1 influenza and parvovirus B19. Physiologic and emergency granulopoesis will also be discussed.
متن کاملAutophagy and polyglutamine diseases
In polyglutamine diseases, an abnormally elongated polyglutamine tract results in protein misfolding and accumulation of intracellular aggregates. The length of the polyglutamine expansion correlates with the tendency of the mutant protein to aggregate, as well as with neuronal toxicity and earlier disease onset. Although currently there is no effective cure to prevent or slow down the progress...
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ژورنال
عنوان ژورنال: International Journal of Cell Biology
سال: 2011
ISSN: 1687-8876,1687-8884
DOI: 10.1155/2011/732798